Volume 8, Issue 0

2021pp 0—0

About the Cover

The cover for Oncoscience Volume 8, 2021 features Figure 5, "Hypothetical scenarios of adding anti-aging treatments to current medical care," from https://doi.org/10.18632/oncoscience.547
by Mikhail V. Blagosklonny

Research Perspectives

Monitoring vascular normalization: new opportunities for mitochondrial inhibitors in breast cancer

Silvana Mouron, Maria J. Bueno, Manuel Muñoz, Miguel Quintela-Fino

https://doi.org/10.18632/oncoscience.523pp 1—13

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Research Papers

The helix-loop-helix transcriptional regulator Id4 is required for terminal differentiation of luminal epithelial cells in the prostate

Dhanushka Hewa Bostanthirige, Shravan K. Komaragiri, Jugal B. Joshi, Majid Alzahrani, Isha Saini, Sanjay Jain, Nathan J. Bowen, Matthew C. Havrda, Jaideep Chaudhary

https://doi.org/10.18632/oncoscience.524pp 14—30

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Research Perspectives

Upper gastrointestinal cancers in Lynch syndrome: the time for surveillance is now

Shria Kumar, Bryson W. Katona

https://doi.org/10.18632/oncoscience.525pp 31—33

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AKT as a therapeutic target for autophagy induction and cancer therapy

Qi Wu, Yi Tu, Guido Kroemer, Oliver Kepp

https://doi.org/10.18632/oncoscience.526pp 34—36

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Causation of increased prostate cancer in young men

Archie Bleyer, Filippo Spreafico, Ronald Barr

https://doi.org/10.18632/oncoscience.527pp 37—39

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Balancing efficacy and quality of life measurements among metastatic renal cell carcinoma (RCC) studies

Jeanny B. Aragon-Ching

https://doi.org/10.18632/oncoscience.528pp 40—45

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Corrections

Correction: Lactate dehydrogenase A inhibition by small molecular entities: steps in the right direction

Btissame El Hassouni, Marika Franczak, Mjriam Capula, Christian M. Vonk, Valentina M. Gomez, Ryszard T. Smolenski, Carlotta Granchi, Godefridus J. Peters, Filippo Minutolo, Elisa Giovannetti

https://doi.org/10.18632/oncoscience.529pp 46

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Research Perspectives

Importance of amino acids in brain parenchyma invasion by cancer cells

Alessio Paone, Amani Bouzidi, Serena Rinaldo, Giorgio Giardina, Francesca Cutruzzolà

https://doi.org/10.18632/oncoscience.530pp 47—49

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Alternative splicing of CERS2 promotes cell proliferation and migration in luminal B subtype breast cancer cells

Trishna Pani, Kajal Rajput, Animesh Kar, Ujjaini Dasgupta

https://doi.org/10.18632/oncoscience.531pp 50—52

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A novel RNA- based approach to counteract EMT

Sabrina Garbo, Marco Tripodi, Cecilia Battistelli

https://doi.org/10.18632/oncoscience.532pp 53—54

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A “two-hit” (chemo)therapy to improve checkpoint inhibition in cancer

Paolo Falvo, Stefania Orecchioni, Alessro Raveane, Giulia Mitola, Francesco Bertolini

https://doi.org/10.18632/oncoscience.533pp 55—57

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p53 activation vs. stabilization: an acetylation tale from the C-terminal tail

Ning Kon, Wei Gu

https://doi.org/10.18632/oncoscience.534pp 58—60

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Research Papers

Constitutive activation of MEK5 promotes a mesenchymal and migratory cell phenotype in triple negative breast cancer

Margarite D. Matossian, Van T. Hoang, Hope E. Burks, Jacqueline La, Steven Elliott, Courtney Brock, Douglas B. Rusch, Aaron Buechlein, Kenneth P. Nephew, Akshita Bhatt, Jane E. Cavanaugh, Patrick T. Flaherty, Bridgette M. Collins-Burow, Matthew E. Burow

https://doi.org/10.18632/oncoscience.535pp 61—71

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Research Perspectives

Radiomic-based diagnostics in oncology: challenges toward clinical practice

Emanuele Barabino, Giovanni Rossi, Alessandro Fedeli, Giuseppe Cittadini, Carlo Genova

https://doi.org/10.18632/oncoscience.536pp 72—73

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SCIRT lncRNA slows the formation of tumour initiating cells in breast cancer

Alex de Giorgio, Lero Castellano

https://doi.org/10.18632/oncoscience.537pp 74—75

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A precision approach to breast cancer treatment based on cell lineage-specific vulnerabilities

Jay S. Desgrosellier

https://doi.org/10.18632/oncoscience.538pp 76—79

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Re-enforcing the strategy of targeting MEK/ERK signaling to overcome acquired resistance to third generation EGFR inhibitors

Wen Zhao, Shi-Yong Sun

https://doi.org/10.18632/oncoscience.539pp 80—81

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Advances in culture methods for acute myeloid leukemia research

Krishnapriya Syama, Eman M. Hassan, Shan Zou

https://doi.org/10.18632/oncoscience.540pp 82—90

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Determining the utility of a screening program to reduce the incidence of HPV driven oropharyngeal cancer

Sarju Vasani, Ian Frazer, Chamindie Punyadeera

https://doi.org/10.18632/oncoscience.541pp 91—93

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New insight into the role of MDMX in MDM2-mediated p53 degradation and anti-cancer drug development

Jing Yang, Yanping Zhang

https://doi.org/10.18632/oncoscience.542pp 94—96

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Tune the channel: TRPM8 targeting in prostate cancer

Alessandro Alaimo, Dario De Felice, Sacha Genovesi, Marco Lorenzoni, Andrea Lunardi

https://doi.org/10.18632/oncoscience.543pp 97—100

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Editorials

Taking action early to manage emergence of acquired resistance to osimertinib or other third generation EGFR inhibitors

Guangzhi Ma, Shi-Yong Sun

https://doi.org/10.18632/oncoscience.544pp 101—102

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Editorial Perspective

The hyperfunction theory of aging: three common misconceptions

Mikhail V. Blagosklonny

https://doi.org/10.18632/oncoscience.545pp 103—107

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Corrections

Correction: Targeting focal adhesion kinase overcomes erlotinib resistance in smoke induced lung cancer by altering phosphorylation of epidermal growth factor receptor

Hitendra S. Solanki, Remya Raja, Alex Zhavoronkov, Ivan V. Ozerov, Artem V. Artemov, Jayshree Advani, Aneesha Radhakrishnan, Niraj Babu, Vinuth N. Puttamallesh, Nazia Syed, Vishalakshi Nanjappa, Tejaswini Subbannayya, Nandini A. Sahasrabuddhe, Arun H. Patil, T.S. Keshava Prasad, Daria Gaykalova, Xiaofei Chang, Rachana Sathyendran, Premendu Prakash Mathur, Annapoorni Rangarajan, David Sidransky, Akhilesh Pandey, Evgeny Izumchenko, Harsha Gowda, Aditi Chatterjee

https://doi.org/10.18632/oncoscience.546pp 108—109

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Research Perspectives

No limit to maximal lifespan in humans: how to beat a 122-year-old record

Mikhail V. Blagosklonny

https://doi.org/10.18632/oncoscience.547pp 110—119

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Clinical Reports

Berry anthocyanidins inhibit intestinal polyps and colon tumors by modulation of Src, EGFR and the colon inflammatory environment

Ashley M. Mudd, Tao Gu, Radha Munagala, Jeyaprakash Jeyabalan, Mostafa Fraig, Nejat K. Egilmez, Ramesh C. Gupta

https://doi.org/10.18632/oncoscience.548pp 120—133

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VTT-006, an anti-mitotic compound, binds to the Ndc80 complex and suppresses cancer cell growth in vitro

Leena J. Laine, Jenni H.E. Mäki-Jouppila, Emma Kutvonen, Pekka Tiikkainen, Thomas K.M. Nyholm, Jerry F. Tien, Neil T. Umbreit, Ville Härmä, Lila Kallio, Trisha N. Davis, Charles L. Asbury, Antti Poso, Gary J. Gorbsky, Marko J. Kallio

https://doi.org/10.18632/oncoscience.549pp 134—153

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