Figure 4.Measurements of SVs concentrations in HGSOC multisite biopsies(A–D) Concentrations (copy numbers per ng sample input) of targeted SVs were measured by ddPCR (digital droplet PCR). Each column represents the mean value of three replicates. Germline control WBC of each HGSOC and NTC were used for all experiments. (A) In HGSOC#1, gDNA of multisite biopsies LOV (left ovary), ROV (right ovary), and RECT (rectus) were used ddPCR and 6 SV targets (SV1-6) were measured. (B) In HGSOC#2, gDNA of multisite biopsies OV (ovary), OM (omentum), and PERI (pericardium) were used for ddPCR and 6 SV targets (SV1-6) were measured. (C) In HGSOC#3, gDNA of multisite biopsies LOV(left ovary), LPELV (left pelvis), and RABD (right abdominum) were used for ddPCR and 5 SV targets (SV1, 3, 4, 7, 8) were measured. (D) In HGSOC#4, gDNA of biopsies OM (omentum) and PELVIS (pelvis) were used for ddPCR and 5 SV targets (SV1-5) were measured.
