Figure 1.Workflow of detection of tumor-informed SVs of HGSOCs in liquid biopsySchematic summary of the workflow: cryopreserved HGSOC multisite biopsies and WBC (white blood cell, germline control) were subjected to WGS (whole genome sequencing), and SVs (structural variants) were identified by multiple algorithms; personalized primers/probes were designed and validated using gDNA (genomic DNA) of HGSOC biopsies before measuring their concentration in liquid biopsy; cfDNA was isolated from fresh frozen plasma.
