Figure 1.Kaplan-Meier (KM) survival and gene expression analyses of TCGA case IDs representing MYC amplification(A) Progression-Free Survival (PFS) of case IDs representing WXS-based CNs of MYC, comparing top 20 CNV ratios (black line, n = 20) and all other CNV ratios (grey line, arrowheads, n = 455), with statistical analysis for the KM plot and the 70-month survival timepoint (log-rank p-value = 0.15; two-proportion time, single time point test p-value = 0.0113) (Supplementary Table 4). (B) PFS of case IDs representing WXS-based CNs of MYC, comparing top 20 CNV ratios (blue line, n = 20) and bottom 20 CNV ratios (gray line, n = 20), with statistical analysis for the KM plot and the 70-month survival timepoint (log-rank p-value = 0.19; two-proportion time, single time point test p-values = 0.0057) (Supplementary Table 5), (C) Correlation of MYC tumor:blood sequencing read ratios (CNV) with the RNAseq values for MYC (r = 0.128, p = 0.005) (Supplementary Table 6).
